- Melting point:
- -57 °C
- Boiling point:
- 115-117 °C(lit.)
- 1.183 g/mL at 25 °C(lit.)
- vapor density
- 3.2 (vs air)
- vapor pressure
- 13.8 mm Hg ( 21.1 °C)
- refractive index
- Flash point:
- 93 °F
- storage temp.
- Refrigerator (+4°C) + Flammables area
- APHA: ≤20
- Specific Gravity
- 1.183 (20/4℃)
- Pungent, garlic; sweet, pungent; like chloroform.
- explosive limit
- Water Solubility
- 6 g/100 mL (10 ºC)
- Henry's Law Constant
- 3.42(x 10-5 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998)
- Exposure limits
- TLV-TWA(skin) 8 mg/m3 (2 ppm) (ACGIH); STEL (15 min) 19 mg/m3 (5 ppm) (NIOSH).
- Stability Unstable. Flammable - note wide explosion limits and low flash point. Vapours may flow along surfaces to source of ignition. Contact with strong oxidisers may lead to fire. Incompatible with strong acids, strong bases, strong oxidizing agents, metal salts, amines, aluminium, chlorine and a variety of chlorine compounds, most com
- CAS DataBase Reference
- 106-89-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Oxirane, (chloromethyl)-(106-89-8)
- EPA Substance Registry System
- Epichlorohydrin (106-89-8)
- Risk and Safety Statements
|RIDADR||UN 2023 6.1/PG 2
|Autoignition Temperature||779 °F|
|HS Code||2910 30 00|
|Toxicity||LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter)|
Epichlorohydrin price More Price(15)
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|Sigma-Aldrich||02578||(±)-Epichlorohydrin analytical standard||106-89-8||1ml||$33.7||2019-12-02||Buy|
|Sigma-Aldrich||45340||(±)-Epichlorohydrin purum, ≥99% (GC)||106-89-8||1l-f||$55.7||2019-12-02||Buy|
|TCI Chemical||E0012||Epichlorohydrin >99.0%(GC)||106-89-8||25g||$17||2019-12-02||Buy|
|TCI Chemical||E0012||Epichlorohydrin >99.0%(GC)||106-89-8||500g||$24||2019-12-02||Buy|
|Alfa Aesar||A15823||(±)-Epichlorohydrin, 99%||106-89-8||500g||$27.7||2019-12-02||Buy|
Epichlorohydrin Chemical Properties,Uses,Production
DescriptionEpichlorohydrin is a kind of organochlorine compound as well as epoxide. It can be used as an industrial solvent. It is a highly reactive compound, and can be used for the production of glycerol, plastics, epoxy glues and resins, and elastomers. It can also be used for the production of glycidyl nitrate and alkali chloride, used as the solvent of cellulose, resins, and paint as well as being used as an insect fumigant. In biochemistry, it can be used as a crosslinking agent for the production of Sephdex size-exclusion chromatography resins. However, it is a potential carcinogen, and can cause various kinds of side effects on respiratory tract and kidneys. It can be manufactured through the reaction between allyl chloride with hypochlorous acid as well as alcohols.
Chemical Propertiescolourless liquid
Chemical PropertiesEpichlorohydrin is a colorless liquid with a slightly irritating, chloroform-like odor.
Physical propertiesClear, colorless, mobile liquid with a strong, irritating, chloroform-like odor. Odor threshold concentration is 0.93 ppm (quoted, Amoore and Hautala, 1983).
UsesEpichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceu-ticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.
UsesSolvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. As stabilizer.
DefinitionChEBI: An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.
General DescriptionA clear colorless liquid with an irritating chloroform-like odor. Density 9.8 lb / gal. Flash point 87°F. Polymerizable. If polymerization takes place inside a closed container, the container is subject to violent rupture. Irritates the skin and respiratory system. Toxic by ingestion. A confirmed carcinogen. Vapors heavier than air. Used to make plastics and as a solvent.
Air & Water ReactionsHighly flammable. Water soluble.
Reactivity ProfileEpichlorohydrin may polymerize exothermically if heated or contaminated. Reacts explosively with aniline. Ignites on contact with potassium tert-butoxide. Reacts with trichloroethylene to give the explosive dichloroacetylene. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids or bases, zinc, aluminum, aluminum chloride, iron, ferric chloride [Sax, 9th ed., 1996, p. 1469].
HazardToxic by inhalation, ingestion, and skin absorption; strong irritant, a carcinogen. Flammable, moderate fire risk. TLV: 0.5 ppm; animal carcinogen.
Health HazardEpichlorohydrin is toxic, carcinogenic, and astrong irritant. Its vapors can produce irrita-tion in the eyes, skin, and respiratory tract.Exposure to high concentration resulted indeath in animals, injuring the central nervoussystem. The liquid can absorb through humanskin, causing painful irritation of subcuta-neous tissues (ACGIH 1986). The symptomsof toxicity from high dosage in test animalswere paralysis of muscles and slow devel-opment of respiratory distress. Long expo-sures at 120 ppm for several hours resultedin lung, kidney, and liver injury in rats(Gage 1959). Ingestion by an oral routecaused tremor, somnolence, and ataxia inmice (NIOSH 1986). The toxic symptomsand lethal doses varied widely with animalspecies. The toxic metabolite of epichlorhy-drin could be ?- chlorohydrin ; thelatter was produced in vitro by rat livermicrosomes (Gingell et al. 1987).
A 25 ppm concentration may be detectableby odor. Exposure at this level may causeburning of the eyes and nose in humans.Above 100 ppm even a short exposure maybe hazardous to humans, causing nausea,dyspnea, lung edema, and kidney injury.
Epichlorohydrin is mutagenic and hasshown carcinogenicity in test animals. Itcaused tumors in the lungs and nose andat gastrointestinal and endocrine sites. Expo-sure to this compound caused harmful repro-ductive effects on fertility and birth defectsin mice.
Health HazardEpichlorohydrin is caustic as both a liquid and gas. Irritation of the eyes and skin, and skin sensitization has been observed. Exposure to epichlorohydrin has caused inflammation of the lungs, asthmatic bronchitis, and liver and kidney damage. In acute poisonings, death may be caused by respiratory paralysis.
Fire HazardWhen heated to decomposition, Epichlorohydrin evolves highly toxic fumes of phosgene and carbon monoxide. Reactive and incompatible with strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of iron and aluminumand compounds with an active hydrogen atom, including water. Unstable, avoid heat, contaminants, strong acids and bases, certain curing agents such as ethylenediamine. Hazardous polymerization may occur.
Chemical ReactivityReactivity with Water Mild reaction; not likely to be hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Can polymerize in presence of strong acids and bases, particularly when hot; Inhibitor of Polymerization: None used.
Contact allergensEpoxy resin of the Bisphenol A type is synthesized from epichlorhydrin and bisphenol A. It leads to bisphenol A diglycidyl ether, which is the monomer ofbisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers of the epoxy resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has, however, been described to occur following exposure to a soil fumigant, due to solvent cement, and in a worker in a pharmaceutical plant, in a division of drug synthesis. Epichlorhydrin was used for the production of drugs propranolol and oxprenolol.
Safety ProfileConfirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Moderately toxic by inhalation. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by inhalation: respiratory, nose, and eyes. Human mutation data reported. A skin and eye irritant. A sensitizer. Flammable liquid when exposed to heat or flame. Explosive reaction with andine. Reaction with trichloroethylene forms the explosive dichloroacetylene. Ignition on contact with potassium tertbutoxide. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids, caustic alkalies, aluminum, aluminum chloride, iron(II1) chloride, or zinc. When heated to decomposition it emits toxic fumes of Cl
Potential ExposureEpichlorohydrin, an organochlorine, is used in the manufacture of many glycerol and glycidol derivatives and epoxy resins; as a stabilizer in chlorine-containing materials; as an intermediate in the preparation of cellulose esters and ethers, paints, varnishes, nail enamels, and lacquers; as a cement for celluloid. It is used as an intermediate in the manufacture of various drugs. Increased cancer risk.
CarcinogenicityEpichlorohydrin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental FateBiological. Bridié et al. (1979) reported BOD and COD values of 0.03 and 1.16 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. When a sewage seed was used in a separate screening test, a BOD value of 0.16 g/g was obtained. The ThOD for epichlorohydrin is 1.21 g/g.
Chemical/Physical. Anticipated products from the reaction of epichlorohydrin with ozone or OH radicals in the atmosphere are formaldehyde, glyoxylic acid, and ClCH2O(O)OHCHO (Cupitt, 1980). Haag and Yao (1992) reported a calculated OH radical rate constant in water of 2.9 x 108/M?sec.
storageEpichlorohydrin is stored in a well-ventilated,cool place isolated from combustible andoxidizable materials, all acids and bases,and anhydrous metal halides. Protect fromphysical damage. It is shipped in metaldrums.
ShippingUN2023 Epichlorhydrin, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid.
Purification MethodsDistil epichlorohydrin under atmospheric pressure, heat it on a steam bath with one-quarter its weight of CaO, then decant and fractionally distil it. [Beilstein 17 V 20.]
IncompatibilitiesMay form explosive mixture with air. Slowly decomposes on contact with water. Heat or strong acids; alkalies, metallic halides, or contaminants can cause explosive polymerization. Violent reaction with strong oxidizers, aliphatic amines; alkanolamines, amines (especially aniline), alkaline earths; chemically active metals (chlorides of aluminum, iron zinc); powdered metals (aluminum, zinc); alcohols, phenols, organic acids; causing fire and explosion hazard. Will pit steel in the presence of water. Thermal decomposition forms highly toxic phosgene gas. May accumulate static electrical charges, and may cause ignition of its vapors.
Waste DisposalIncineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal
Epichlorohydrin Preparation Products And Raw materials
- General Properties of Epichlorohydrin
- Epichlorohydrin (abbreviated ECH) is an organochlorine compound and an epoxide. It is a colorless liquid with a pungent, garli....
- Nov 8，2019
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α-Epichlorohydrin Manufacturer; In stock GMP Factory
|US $1.00 / KG||1KG||High quality manufacturer||TOP 3 largest production factory in China||Chemwill Asia Co.,Ltd.|
|US $1.00 / KG||1KG||99%||20T||Shaanxi Dideu Medichem Co. Ltd|
|US $1.00 / KG||1KG||98%||2 Ton/Tons per Week 106-89-8||Hebei Xibaijie Biotechnology Co., Ltd.|
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- ColesevelaM IMpurity (Epichlorohydrin)
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