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中国福彩网丹东字谜图:Triclosan

Disinfectants Carcinogenicity Toothpaste Standard Chemical Properties Uses Production method
Triclosan
Triclosan structure
CAS No.
3380-34-5
Chemical Name:
Triclosan
Synonyms
ch3565;IRGASAN;TROX-100;TRICLOSAN;TRICHLOSAN;Cloxifenol;ZilesanUW.;Irgacare MP;irgasandp300;Trichlorosan
CBNumber:
CB6771432
Molecular Formula:
C12H7Cl3O2
Formula Weight:
289.54
MOL File:
3380-34-5.mol

Triclosan Properties

Melting point:
56-60 °C(lit.)
Boiling point:
290°C(lit.)
Density 
1.4214 (rough estimate)
refractive index 
1.4521 (estimate)
storage temp. 
Refrigerator
solubility 
H2O: soluble12g/L at 20°C
form 
Solid
pka
7.9(at 25℃)
color 
colorless or white
Water Solubility 
Soluble in ethanol, methanol, diethyl ether and sodium hydroxide solution (1M). Slightly soluble in water.
Merck 
14,9657
BRN 
2057142
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
XEFQLINVKFYRCS-UHFFFAOYSA-N
CAS DataBase Reference
3380-34-5(CAS DataBase Reference)
NIST Chemistry Reference
Triclosan(3380-34-5)
EPA Substance Registry System
Triclosan (3380-34-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H400-H315-H319-H410
Precautionary statements  P305+P351+P338-P273-P501-P391-P264-P280a-P321-P332+P313-P337+P313
Hazard Codes  Xi,N
Risk Statements  36/38-50/53-36/37/38
Safety Statements  26-39-46-60-61-24/25-22-36
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  KO1100000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29095000

Triclosan price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 647950-M Triclosan 3380-34-5 1gm-m $79.1 2019-12-02 Buy
Sigma-Aldrich 1682206 Triclosan United States Pharmacopeia (USP) Reference Standard 3380-34-5 200mg $352.8 2019-12-02 Buy
TCI Chemical T1872 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether >98.0%(GC) 3380-34-5 25g $34 2019-12-02 Buy
TCI Chemical T1872 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether >98.0%(GC) 3380-34-5 100g $94 2019-12-02 Buy
Alfa Aesar L18655 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 99% 3380-34-5 100g $132 2019-12-02 Buy

Triclosan Chemical Properties,Uses,Production

Disinfectants

Triclosan is an efficient broad-spectrum topical antimicrobial disinfectant which is normally white or off-white crystalline powder. It has a slightly phenolic odor. It is insoluble in water but easily soluble in organic solvents and alkali. It has a relative stable chemical property and is heating-resistant and also resistant to acid and alkali hydrolysis without generating any symptoms of the toxicity and environmental pollution. It is internationally recognized as a fungicide variety with specific efficacy. It can kill bacteria such as Staphylococcus aureus, Escherichia coli and fungi such as Candida albicans. It also has an inhibitory effect on the virus (e.g., hepatitis B virus, etc.) while being able to protect the beneficial bacteria. The mechanism of action of triclosan is as below: it is first adsorbed on the bacterial cell wall and then further penetrates through the cell wall and has reaction with the lipid and protein in the cytoplasm, and thus resulting in protein denaturation which further kill the bacteria. Currently it has been widely applied to highly-efficient medicated soap (health soap, health lotion), removing underarm odor (foot aerosol), hand sanitizer, wound disinfectant sprays, medical equipment disinfectants, hygiene cleanser (cream), and air fresheners and refrigerator deodorants and some other daily chemicals. It is also used for the cleaning of the health fabric and the anti-corrosion treatment of plastics. Its high purity version can be added to the toothpaste and mouthwash for treatment of gingivitis, periodontitis and oral ulcers. The State content must not exceed 0.3%.

Carcinogenicity

In 2004, a teacher (Dr. Peter Vikesland) from the Virginia Tech University (US) had found from the experiments that the reaction between the triclosan-containing product and the chlorine-containing tap water containing can generate a substance known as "chloroform aryl", that is, chloroform (chemical name: trichloromethane) which is a colorless, volatile liquid with a special sweetness. Upon exposure to light, it will be oxidized to generate hydrogen chloride and phosgene. It had been once used as an anesthetic. Animal experiments have found that this substance will do harm to the heart and liver with mild teratogenicity and can induce the liver cancer of mice. However, so far no studies on the human carcinogenicity have been reported. For insurance purposes, both the International Cancer Research Centre and the United States have already has the chloroform be listed as suspected carcinogens to the human body.

Toothpaste Standard

The national standard of the toothpaste used in China is the new national standard of toothpaste (GB8372-2008) implemented on February 1, 2009. Compared with the 2001 version of toothpaste standard, the new national standard has been supplemented and adjusted in various aspects. In the new national standard of toothpaste, the prohibited or restricted ingredients include nearly 1,500 kinds, including diethylene glycol and triclosan. The provision of diethylene glycol is that it is not allowed to artificially add it to the raw materials, such as being introduced as impurities. Its content in the toothpaste should not exceed 0.1%. Triclosan were listed as being allowable preservatives but with the usage amount not exceeding 0.3%. The new national standard has ruled that the fluorine content of the fluoride-containing toothpaste should be within the range of 0.04%-0.15%, and the fluoride content should be within the range of 0.05% to 011% for children fluoride-containing toothpaste.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemical Properties

It is colorless and long needle-like crystals with a melting point being around 54-57.3 ℃ (60-61 ℃). It is slightly soluble in water and soluble in ethanol, acetone, ethyl ether and alkali solution. It has a chloro-phenol odor.

Uses

1. It can be used as antiseptic and fungicide and applied to cosmetics, emulsions and resins; also can be used for the manufacture of disinfection medicated soap. The LD50 of mice subject to oral administration of this product is 4g/kg.
2. It can be used for the production of top-grade daily chemical product, the disinfectants of medical instrument as well as diet instrument as well as the preparation of the anti-bacterial, deodorant finishing agent of fabric.
3. It can also be applied to biochemical studies. It is a kind of broad-spectrum antimicrobial agents which inhibit the type II fatty acid synthase (FAS-II) of bacteria and parasites, and also inhibits the mammalian fatty acid synthase (FASN), and may also have anticancer activity

Production method

1. Take 2, 4-dichloro-phenol as the raw material; use 2,4-dichloro-phenol to react with potassium hydroxide to generate dichlorophenol potassium which further reacts with 2,5-dichloro-nitrobenzene in the catalysis of copper for generation of 2,4,4-trichloro-2'-nitro diphenyl ether. It is further reduced by iron powder to generate 2, 4, 4-trichloro-2'-amino diphenyl ether, and then further went through diazotization hydrolysis to obtain the product.
2. Take o-methoxyphenol as the raw material: have potassium hydroxide powder reacted with guaiacol to generate guaiacol potassium. Apply reaction between bromobenzene and methoxy ether, together with chlorine for chlorination to obtain 2, 4, 4’-trichloro-2'-methoxydiphenyl ether. Take AICI3 as hydrolysis catalyst to generate 2,4,4'-trichloro-2'-hydroxydiphenyl ether.

Chemical Properties

Solid

Uses

Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.

Uses

anticonvulsant

Uses

Bacteriostat and preservative for cosmetic and detergent preparations.

Uses

triclosan is a preservative considered to have a low sensitizing potential in leave-on preparations.

Definition

ChEBI: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodo ants as well as in household items such as plastic chopping boards, sports equipment and shoes.

Indications

Triclosan is a broad-spectrum antimicrobial compound. It was originally used in soaps, antiperspirants, and cosmetic toiletries as a germicide. Today, triclosan is incorporated into toothpaste because of its wide spectrum of antimicrobial activities and low toxicity.

brand name

Stri-Dex Cleansing Bar (Sterling Health U.S.A.); Stri-Dex Face Wash (Sterling Health U.S.A.).

Mechanism of action

Triclosan is active against a broad range of oral grampositive and gram-negative bacteria.The primary target of its antibacterial activity is the bacterial cell membrane. High concentrations cause membrane leakage and ultimately lysis of the bacterial cell. Effects at lower concentration are more subtle. Triclosan has been shown to bind to cell membrane targets and inhibit enzymes associated with the phosphotransferase and proton motive force systems.

Pharmacology

Triclosan is retained in dental plaque for at least 8 hours, which in addition to its broad antibacterial property could make it suitable for use as an antiplaque agent in oral care preparations. However, the compound is rapidly released from oral tissues, resulting in relatively poor antiplaque properties as assessed in clinical studies of plaque formation.This observation is further corroborated by a poor correlation between minimal inhibitory concentration values generated in vitro and clinical plaque inhibitory properties of triclosan. Improvement of substantivity was accomplished by incorporation of triclosan in a polyvinyl methyl ether maleic acid copolymer (PVM/MA, Gantrez). With the combination of PVM/MA copolymer and triclosan, the substantivity of the triclosan was increased to 12 hours in the oral cavity.

Clinical Use

Triclosan plus copolymer is available in toothpaste. Commercially available dentifrice concentrations contain 0.3% triclosan and 2.0% PVM/MA copolymer.

Side effects

Triclosan is a preservative used in health care and consumer products, including soaps, deodorants, mouthwashes, toothpastes, cosmetics, and topical medicaments. Ozkaya et al. described a case of suspected immune mediated Cou to triclosan. A 44-year-old female reported experiencing an immediate localized urticarial response after contact with numerous topical products. The use of a toothpaste had also resulted in swelling of her lips, tongue, and breathing difficulties. She also experienced lip swelling after kissing her husband who had used the same product and wheals involving her face after kissing friends on the cheek who had used certain topical products on their faces. The suspected products all contained triclosan 0.2%–0.5%. A severe localized urticarial reaction occurred with open testing to 2% triclosan within 15 minutes. No tests were performed to confirm an immunological mechanism; however, the authors suspected this to be the case because of a positive urticarial response to triclosan within 15 minutes, a history of angioedema to the triclosan-containing toothpaste, and because no immediate reactions were seen in five control subjects who were open tested to 2% triclosan.

Veterinary Drugs and Treatments

Found in several products, often with other active ingredients, triclosan’s antibacterial effects may be useful in treating superficial pyodermas.
Triclosan is a bis-phenol disinfectant/antiseptic. It has a activity against a wide range of organisms, including both gram-positive and gram-negative bacteria and acts via inhibiting bacterial fatty acid synthesis leading to disruption of cell membrane integrity. Triclosan reportedly is not effective against Pseudomonas spp. and may be less effective against staphylococci than either chlorhexidine or ethyl lactate.

Triclosan Preparation Products And Raw materials

Raw materials

Preparation Products


Triclosan Suppliers

Global( 398)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 [email protected] CHINA 207 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 [email protected] CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
[email protected] CHINA 21686 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 [email protected] CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 [email protected] CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 [email protected] China 1870 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 [email protected] CHINA 575 58
career henan chemical co
+86-371-86658258
[email protected] CHINA 29996 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
[email protected] CHINA 136 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 [email protected];[email protected];[email protected];[email protected] CHINA 23981 58

View Lastest Price from Triclosan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-26 Triclosan
3380-34-5
US $10.00 / KG 1KG 99.9% 10 MT Hebei Guanlang Biotechnology Co., Ltd.
2019-10-28 Triclosan
3380-34-5
US $2.00 / Kg/Drum 25Kg/Drum 99% 1ton HubeiwidelychemicaltechnologyCo.,Ltd
2018-12-22 Triclosan
3380-34-5
US $2.00 / kg 1kg 99% ask career henan chemical co

Triclosan Spectrum


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