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中国福彩网官方:Oseltamivir phosphate

Anti-influenza virus Uses
Oseltamivir phosphate
Oseltamivir phosphate structure
CAS No.
204255-11-8
Chemical Name:
Oseltamivir phosphate
Synonyms
SOT;Oselt;SNU-520 Cell;SNU-520 Cells;OseltaMir phosphate;Olstamivir Phosphate;Oseltamivir phosphat;OSELTAMIVIR PHOSPHATE;Osteltamivir phosphate;NTERMEDIATES OF OSELTAMIVIR
CBNumber:
CB2119221
Molecular Formula:
C16H31N2O8P
Formula Weight:
410.4
MOL File:
204255-11-8.mol

Oseltamivir phosphate Properties

Melting point:
196-198°C
storage temp. 
-20°C Freezer
solubility 
H2O: soluble30mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -26 to -36°, c = 1 in H2O
InChIKey
PGZUMBJQJWIWGJ-IFAKAUOZSA-N
CAS DataBase Reference
204255-11-8(CAS DataBase Reference)
FDA UNII
4A3O49NGEZ
SAFETY
  • Risk and Safety Statements
HazardClass  IRRITANT
HS Code  2924299500

Oseltamivir phosphate price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1781 Oseltamivir phosphate Pharmaceutical Secondary Standard; Certified Reference Material 204255-11-8 500mg $116 2019-12-02 Buy
Sigma-Aldrich 1479304 Oseltamivir phosphate United States Pharmacopeia (USP) Reference Standard 204255-11-8 200mg $460.6 2019-12-02 Buy
Cayman Chemical 16070 Oseltamivir (phosphate) ≥98% 204255-11-8 250mg $93 2018-11-13 Buy
Cayman Chemical 16070 Oseltamivir (phosphate) ≥98% 204255-11-8 100mg $39 2018-11-13 Buy
Sigma-Aldrich SML1606 Oseltamivir phosphate ≥98% (HPLC) 204255-11-8 100mg $62.8 2019-12-02 Buy

Oseltamivir phosphate Chemical Properties,Uses,Production

Anti-influenza virus

Oseltamivir phosphate is a kind of anti-influenza drugs, under the trade name Tamiflu. Its appearance exhibits as white to yellowish-white powder. It can be divided into type A (alpha) and B (Beta) selective inhibitor of the influenza virus neuraminidase and can prevent the release of virus from infected cells, through inhibiting the activity of the influenza virus neuraminidase, thus achieving the purpose of control of influenza symptoms. Clinically it can be used for treatment of the type A influenza and type B influenza in adults and children of 1 year old or over 1 year old as well as the clinical prevention of influenza A and B in adult and adolescent of 13 year old or over 13 years old.
Oseltamivir phosphate can subject to rapid metabolism into oselatamivr carboxylate after gastrointestinal absorption with 75% of the total oral administrated dose participating in the systemic circulation in the from of oselatamivr carboxylate. The active ingredient of this drug is a potent and unique neuraminidase inhibitors acting on all the processes of influenza virus infection, preventing the replication of all clinically relevant influenza virus strains A or B strain. It has obvious inhibitory effect even in nanomolar concentration in vitro. It has ben observed in vitro that the active metabolite can inhibit the growth of influenza virus as well as in vivo that it can inhibit the replication and pathogenicity of influenza virus. This product, through inhibiting the release of virus from infected cells, can reduce the spread of influenza A or B virus.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Uses

Antibiotics and anti-virus

Description

Oseltamivir was launched in the US and Switzerland for the treatment of influenza infections by all common strain viruses. It can be obtained by at least 2 different ways including a novel 12-step synthesis from (-)-quinic acid. Oseltamivir is the ethyl ester prodrug of GS-4071, the corresponding acid, which is one of the most potent inhibitors of both influenza A and B virus neuraminidase (sialidase) isoenzymes; these glycoproteins are expressed on the virion surface and are essential for virus replication for both A and B strains. Oseltamivir emerged as one of the first two neuraminidase inhibitors to reach the market. GS-4071 demonstrated a low (< 5%) oral bioavailability in animals due to a poor absorption from the gastrointestinal barrier; by incorporating a more lipophilic ester group, the oral bioavailabilty can reach 30 to 100% in mice, rats and dogs. Following oral administration of Oseltamivir in rats, a similar concentration of GS-4071 was found in the bronchoalveolar lining fluid and the plasma which indicated a good penetration of the active compound into the lower respiratory tract. In mice, chickens and ferrets, orally administered Oseltamivir was found to have significant inhibitory effects on A and B influenza infections in protecting against a lethal challenge of virus and lessening virus titer in the lungs or nasal washings. In several clinical trials with patients receiving oral capsules daily, Oseltamivir was shown to be effective in reducing significantly the duration and severity of the clinical symptoms, including fever, cough and general malaise, in both early treatment and prevention.

Chemical Properties

White Cyrstalline Solid

Originator

Gilead (US)

Uses

Orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug.

Uses

Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its

Uses

An antiviral agent

brand name

Tamiflu (Roche).

General Description

receptor site showed clearly that additional binding sitesexist for the C-5 acetamido carbonyl group and the arginineresidue at position 152 of the receptor site. In addition, the C-2 carboxyl group of sialic acid binds to Arg 118, Arg 292, andArg 371. Position C-6 is capable of undergoing a hydrophobicinteraction with various amino acids, including Glu, Ala,Arg, and Ile. Maximum binding to neuraminidase occurswhen the C-6 substituent is substituted with a nonpolar chain.In oseltamivir, this nonpolar group is 3-pentyl. An importantfeature of oseltamivir is the ethyl ester, which makes the drugorally efficacious. This drug is the first orally active agent foruse against influenza A and B. It is also indicated for the treatmentof acute illness. If administered within 2 days after theonset of influenza symptoms, the drug is effective.

Veterinary Drugs and Treatments

Although, there is no research published (at the time of writing— January 2007) documenting oseltamivir safety or efficacy in dogs or cats, there is much interest and discussion regarding its potential for the adjunctive treatment of parvovirus infections in dogs. It may be of benefit for adjunctive treatment of other viral infections, particularly those with associated secondary bacterial components, but research or experience is lacking. A recent study performed in horses, experimentally infected with equine influenza A (H3N8), documented some efficacy in the attenuation of clinical signs (pyrexia), viral shedding, and secondary bacterial pneumonias (Yamanaka, Tsujimura et al. 2006).
Because oseltamivir is the primary antiviral agent proposed for treatment or prophylaxis for an H5N1 influenza (“bird flu”) pandemic in humans, its use in veterinary patients is controversial, particularly due to concerns of adequate drug supply for the human population and the potential for influenza virus resistance development. In 2006, the FDA banned the extra-label use of oseltamivir and other influenza antivirals in chickens, turkeys and ducks. At the time of writing, its use is still allowed in mammal veterinary patients, but veterinarians should use the drug prudently and be cognizant of these public health concerns.

Oseltamivir phosphate Preparation Products And Raw materials

Raw materials

Preparation Products


Oseltamivir phosphate Suppliers

Global( 261)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 [email protected] CHINA 305 58
Shenzhen Excellent Biotech Co., Ltd.
13928901708
[email protected];[email protected] CHINA 882 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 [email protected] CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 [email protected] CHINA 22631 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 [email protected] CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
[email protected] CHINA 3015 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:[email protected]
+86-21-34979012 [email protected] CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 [email protected] CHINA 24697 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
[email protected] CHINA 3623 58
career henan chemical co
+86-371-86658258
[email protected] CHINA 30052 58

View Lastest Price from Oseltamivir phosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-27 Oseltamivir phosphate
204255-11-8
US $15.00 / KG 1KG 98% 1000KG career henan chemical co

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